Time to Broaden Warning on Fluoroquinolones to All Adults?

A new study confirms and strengthens the association between fluoroquinolone antibiotics and increased risk of aortic aneurysm, prompting calls to broaden warnings to include all adults, not just high-risk adults.

In December 2018, the U.S. Food and Drug Administration (FDA) updated its May 2017 safety alert stating that fluoroquinolone antibiotics should not be used in patients at increased risk of aortic disease.

The new study, published in JAMA Surgery, suggests that fluoroquinolones “should be used with caution among individuals aged 35 years or older, regardless of sex or comorbidities,” say Dr. Melina Kibbe and colleagues with the University of North Carolina at Chapel Hill.

Continue reading

Heightened Brain Activity With Stress Tied to Takotsubo Syndrome

A new study is providing what researchers are calling “unique and important insights” into potential mechanisms contributing to the Takotsubo syndrome (TTS) also known as “broken heart syndrome.”

Results from the retrospective case-control study suggest that chronically heightened stress-associated neurobiological activity may affect both the risk for, and timing of, subsequent TTS.

“The findings suggest that this stress-related acute syndrome doesn’t start simply upon exposure to a stressor, that preexisting brain wiring predates it by quite a while,” study author Ahmed Tawakol, MD, director of nuclear cardiology and co-director of the Cardiovascular Imaging Research Center at Massachusetts General Hospital and Harvard Medical School, Boston, told Medscape Medical News.

The study highlights the need to “pay close attention” to stress reduction in patients who develop TTS as they may face ongoing problems, said Tawakol.

“We should test whether reducing stress leads to health benefits in this subpopulation of patients who develop this syndrome,” he added.

Continue reading

The Efficacy of Immune Checkpoint Inhibitors in Anaplastic Lymphoma Kinase‐Positive NSCLC

Continue reading

Pneumatosis Intestinalis in the Adult : Benign to Life-Threatening Causes

Continue reading