A large study from the United Kingdom reveals the breadth of neurologic and neuropsychiatric complications of COVID-19 infection, including stroke, psychosis, altered mental state, and dementia-like syndrome.
“Clinicians should be alert to the possibility of patients with COVID-19 developing these complications and, conversely, of the possibility of COVID-19 in patients presenting with acute neurological and psychiatric syndromes,” the investigators, from the CoroNerve Study Group, write.
The report was published online June 25 in Lancet Psychiatry.
Altered Mental State, New-Onset Psychosis
During the exponential phase of the pandemic, Benedict Michael, PhD, from the University of Liverpool, and colleagues set up an online case reporting platform called CoroNerve to investigate the range of COVID-19 complications that affect the brain.
Colchicine, an anti-inflammatory drug used to treat gout and rheumatic disease, may be a promising treatment for COVID-19, a randomized, open-label trial suggests.
In the Greek Study in the Effects of Colchicine in COVID-19 Complications Prevention (GRECCO-19), investigators randomly assigned 105 patients who had COVID-19 to receive either the standard of care or the standard of care plus colchicine for 3 weeks. They found that for patients in the colchicine group, the time to clinical deterioration improved, although there were no significant differences between the groups in cardiac and inflammatory biomarkers.
“Colchicine is an old drug utilized for its anti-inflammatory and antimitotic effects,” lead author Spyridon Deftereos, MD, PhD, professor of cardiology, Second Department of Cardiology, “Attikon” University Hospital National and Kapodistrian University of Athens, told theheart.org | Medscape Cardiology.