Dr.S.Harsha Vardhan

8th June 202013th June 2021

Adjuvant Osimertinib Extends Disease Free Survival in Localized Non-Small Cell Lung Carcinoma

Adjuvant therapy with osimertinib was associated with a nearly 80% reduction in the risk of disease recurrence or death in patients with stage IB-IIIA non–small cell lung cancer (NSCLC) bearing EGFR mutations, results of the ADAURA trial showed.

The randomized, phase 3 trial was a comparison of osimertinib treatment with placebo following complete resection of localized or locally advanced NSCLC with negative margins. The trial was unblinded early and halted on the recommendation of the independent data-monitoring committee, due to the efficacy of osimertinib.

“If I were on the committee, I would have done the same thing. These are extraordinary results,” said study investigator Roy S. Herbst, MD, PhD, chief of medical oncology at the Yale Cancer Center and Smilow Cancer Center at Yale University in New Haven, Conn.

Dr. Herbst is scheduled to present results from ADAURA as part of the American Society of Clinical Oncology virtual scientific program.

8th June 202013th June 2021

COVID-19 : Eat Right During Pandemic

8th June 202013th June 2021

PPI Added to Chemotheraphy Improves Breast Tumor Response Rate

The proton pump inhibitor (PPI) omeprazole may be a useful addition to treatment for triple-negative breast cancer, as it boosted the expected rate of tumor disappearance among women with early-stage disease, according to the results of a phase 2 trial.

The trial results are presented online at the 2020 virtual annual meeting of the American Society of Clinical Oncology.

The rationale behind the approach includes the fact that PPIs inhibit fatty acid synthase (FASN), an enzyme overexpressed in 70% of newly diagnosed triple-negative breast cancers (TNBC) and associated with poor prognosis.

In the study, omeprazole, a generic drug for gastroesophageal reflux, was added to standard chemotherapy. Both were given to 42 women as neoadjuvant treatment in the weeks before breast surgery at five US centers in the single-arm study.

7th June 202013th June 2021

Clinical Practice Guidelines on The Treatment of Left-Sided Colonic Diverticulitis (ASCRS, 2020)

Clinical practice guidelines for the treatment of left-sided colonic diverticulitis were released in June 2020 by the American Society of Colon and Rectal Surgeons

Acute Diverticulitis Initial Evaluation

For the initial evaluation of suspected acute diverticulitis, include (1) a problem-specific history, (2) physical examination, and (3) appropriate laboratory evaluations.

The most appropriate initial imaging modality for assessing suspected diverticulitis is an abdominal and pelvic CT scan.

If CT scanning is contraindicated or unavailable, useful alternatives include ultrasonography and MRI.

7th June 202013th June 2021

Guidelines for Operative & Nonoperative Management of Liver Trauma (WSES, 2020)

The guidelines on management of liver trauma were published on March 30, 2020, by the World Society of Emergency Surgery (WSES)

Nonoperative Management

In the absence of other internal injuries requiring surgery, nonoperative management should be the treatment of choice for all hemodynamically stable minor (WSES I; American Association for the Study of Trauma [AAST] I-II), moderate (WSES II; AAST III), and severe (WSES III; AAST IV-V) injuries.

In transient responders with moderate and severe injuries, nonoperative management should be considered only in selected settings where there is immediate availability of trained surgeons, operating rooms (ORs), continuous monitoring (ideally in an intensive care unit [ICU] or emergency department [ED]), and access to angiography (AG), angioembolization (AE), blood and blood products; and in locations where a system exists to quickly transfer such patients to higher-level-of-care facilities.